Nanovaccine Design

The use of nanoparticles to optimise the delivery of vaccines to generate the best immune response has been demonstrated recently in a model vaccine for Y. Pestis. The key ideas are the decoration of the nanoparticle not just with the target proteins but also with other factors that may be immunogenic. We are developing a number of new chemistries to attached polysaccharides to the nanoparticle surface that mimic the external structure of bacteria. We are also developing an in vitro assay of the performance of the nanoparticle vaccine using cell culture techniques.

Aims and Objectives

The aim of the project is to decorate a novel nanoparticle vaccine with immunogenic chemistry that will produce an intense immune response. Careful choice of immunogenic species may also control the MHC1/MHC2 presentation of antigens.

  • Design and build new nanovaccine candidates
  • Develop in vitro assay technology
  • Control MHC1 and MCH2 response
  • Characterise the antibodies and concentration produced by the antibodies.


Gregory, A.E., Williamson, E.D., Prior, J.L., Butcher, W.A., Thompson, I.J., Shaw, A.M., Titball, R.W. (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine, 30(48), 6777-6782

Gregory AE, Shaw AM, Titball RW, Williamson ED, Prior JL, Butcher WA, Thompson IJ
Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity
Vaccine 2012

Nanovaccine Design

Nanovaccine Design

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