The evolutionary genetics of pathogenic trypanosomes
This work is a long-running collaborative programme (with Prof Wendy Gibson, Bristol) on the evolutionary genetics of pathogenic trypanosomes (with special reference to the human pathogens, Trypanosoma brucei and Trypanosoma cruzi) and utilises sequence data from a range of genes, including the 18S ssu rRNA and the mini-exon.
Phylogenetic analysis of these data has allowed a re-evaluation of the evolutionary relationships of these important disease agents (see Figure) and, for the first time, has provided evidence of a divergent late-Cretaceous origins for the two forms of human-infective trypansomes; see Zimmer, C. (2001), Genetic Trees Reveal Disease Origins, Science 292: 1090.
Stevens, J.R., Noyes, H.A., Dover, G.A. & Gibson, W.C. (1999) The ancient and divergent origins of the human pathogenic trypanosomes, Trypanosoma brucei and T. cruzi. Parasitology 118: 107-116. [View PDF]
Stevens, J. & Gibson, W. (1999) The evolution of Salivarian trypanosomes. Mem. Inst. Oswalso Cruz 94: 225-228. [View PDF]
Stevens, J.R., Noyes, H.A., Schofield, C.J. & Gibson, W. (2001) The Molecular Evolution of Trypanosomatidae. Advances in Parasitology 48: 1-56. [PDF (11.5 Mb) available on request]
Stevens, J. & Rambaut, A. (2001) Evolutionary rate differences in trypanosomes. Infection, Genetics and Evolution 1: 143-150. [View PDF]
Michon, P., Stevens, J.R., Kaneko, O. & Adams, J.H. (2002) Evolutionary relationships of conserved cysteine-rich motifs in adhesive molecules of malaria parasites. Molecular Biology and Evolution 19: 1128-1142. [PDF/reprint available on request]
Hamilton, P.B., J.R. Stevens, M.W. Gaunt, J. Gidley & W.C. Gibson (2004) Trypanosomes are monophyletic: evidence from genes for glyceraldehyde phosphate dehydrogenase and small subunit ribosomal RNA. International Journal for Parasitology, 34: 1393-1404. [PDF available on request]
Hamilton, P. B., J. R. Stevens, P. Holz, B. Boag, B. Cooke and W. C. Gibson (2005) The accidental introduction of the trypanosome of the introduced European rabbit (Oryctolagus cuniculus) to Australia and its potential for biocontrol. Molecular Ecology, 35: 431–443. [PDF available on request]
Simpson, A.G.B., Stevens, J.R. and Lukes, J. (2006) The evolution and diversity of kinetoplastid flagellates. Trends in Parasitology, 22 (4): 168-174. [PDF available on request]
Hamilton, P.B., Gibson, W.C. and Stevens, J.R. (2007) Patterns of co-evolution between trypanosomes and their hosts deduced from ribosomal RNA and protein-coding gene phylogenies. Molecular Phylogenetics and Evolution, 44 (1): 15-25. [PDF available on request]
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