Richards Group

Living Systems Institute, University of Exeter

Current collaborators include:

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Most recent publications:

  • Richards DM: Receptor models of phagocytosis: the effect of target shape. Adv Exp Med Biol 1246:55-70 (PubMed)
  • Richards DM, Walker JJ, Tabak J: Ion channel noise shapes the electrical activity of endocrine cells. PLoS Comput Biol 16(4):e1007769 (PubMed)
  • Passmore JB, ..., Richards DM, ..., Schrader M: Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation. Biochim Biophys Acta Mol Cell Res (PubMed)
  • Castro IG, Richards DM, et al. (2018): A role for MIRO1 in motility and membrane dynamics of peroxisomes. Traffic 19:229-42 (PubMed)
  • Richards DM, Endres RG (2017) How cells engulf: a review of theoretical approaches to phagocytosis. Rep Prog Phys 80:126601 (PubMed)
  • Richards DM, Endres RG (2016) Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis. Proc Natl Acad Sci USA 113(22):6113-8 (PubMed)
  • Richards DM, Saunders TE (2015) Spatiotemporal analysis of different mechanisms for interpreting morphogen gradients. Biophys J 108:2061-73 (PubMed)
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We are grateful for funding from:

Phagocytosis is the fascinating process by which our immune cells engulf and destroy foreign particles. How easily such cells can destroy a foreign particle depends crucially on the particle shape and size, and the direction that the cell meets the particle. This is directly relevant to the design of microparticle drug delivery systems (tiny particles that can be used to carry drugs) since such particles must be carefully designed to avoid removal via phagocytosis. Click below for a gentle introduction to these topics and how our work is helping.

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Contact information and links

Address: Living Systems Institute, University of Exeter, Exeter EX4 4SB, UK


Phone: +44 (0)1392 727483

YouTube: David Richards Group

Twitter: Richards Group

Networks: Exeter Quantitative Health Network