Published Articles in Refereed Journals

B. Wheeler, J. Allen, M. Depledge and A. Curnow Radon and skin cancer in Southwest England: an ecologic study Epidemiology Volume 23 Issue 1 44-52 2012

E. Blake, J. Allen, C. Thorn, A. Shore, A. Curnow.  Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methylaminolevulinate photodynamic therapy. Lasers in Medical Science  ISSN 0268-8921 2012

E. Blake, S. Campbell, J. Allen, J. Mathew, P. Helliwell and A. Curnow The time-dependent accumulation of protoporphyrin IX fluorescence in nodular basal cell carcinoma following application of methyl aminolevulinate with an oxygen pressure injection device Journal of Photochemistry and Photobiology B Biology Volume 117  97-103  2012

J. Tyrrell, S.M. Campbell and A. Curnow Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification. Photodiagnosis and Photodynamic Therapy Volume 8 Issue 1 30 - 38 2011

J. Tyrrell, S. Campbell and A. Curnow The effect of air cooling relief on Protoporphyrin IX photobleaching and clinical efficacy during dermatological photodynamic therapy Journal of Photochemistry and Photobiology. B, Biology Volume 103 Issue 1 1 - 7 2011

J. Tyrrell, C. Morton, S. Campbell and A. Curnow Comparison of Protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites British Journal of Dermatology Volume 164 Issue 6 1362-1368 2011

J. Tyrrell, C. Thorn, A. Shore, S.Campbell and A.Curnow Oxygen saturation and perfusion changes during dermatological methylaminolaevulinate photodynamic therapy British Journal of Dermatology Volume 165 Issue 6 1323-1331 2011

E. Blake, J. Allen and A. Curnow An in vitro comparison of the effects of the iron-chelating agents, CP94 and dexrazoxane, on Protoporphyrin IX accumulation for photodynamic therapy and/or fluorescence guided resection Photochemistry and Photobiology Volume 87 Issue 6 1419-1426 2011

J. Tyrrell, S. Campbell and A. Curnow. The validation of a non-invasive fluorescence imaging system to monitor clinical dermatological photodynamic therapy. Photodiagnosis and Photodynamic Therapy Volume 7 86-97 2010

H. Malhomme de la Roche, S. Seagrove, A. Mehta, P. Divekar, S. Campbell and A. Curnow Using natural dietary sources of antioxidants to protect against ultraviolet and visible radiation-induced DNA damage: An investigation of human green tea ingestion Journal of Photochemistry and Photobiology B: Biology 101 Issue 2 169-173 2010

E. Blake and A. Curnow The hydroxypyridinone iron chelator CP94 can enhance PpIX-induced PDT of cultured human glioma cells Photochemistry and Photobiology Volume 86, Issue 5 1154 - 1160 2010

J. Morris, T. Laing-Morton, P. Marno and A. Curnow An investigation into the awareness and understanding of the ultraviolet index forecasts in the South West of England. Phoatochemical and Phaotobiological Sciences 10 103-108 2010

S. Campbell, J. Tyrrell, R. Marshall and A. Curnow Effect of ALA/MAL-photodynamic therapy on hypertrophic scarring. Photodiagnosis and Photodynamic Therapy Volume 7, Issue 3 183-188 2010

J. Tyrrell, S. Campbell and A. Curnow The relationship between protoporphyrin IX photobleaching during real-time dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) and subsequent clinical outcome Lasers and Surgery in Medicine Volume 42, Issue 7 613 - 619 2010

J. Tyrrell, S. Campbell and A. Curnow Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological MAL-PD.T Photodiagnosis and Photodynamic Therapy Volume 7 Issue 4 232-238 2010

J. Morris, T. Laing-Morton, P. Marno and A. Curnow An investigation into the awareness and understanding of the ultraviolet index forecasts in the South West of England Photochemical and Photobiological Sciences 10 103-108 2010

J. Tyrrell, S. Campbell and A. Curnow Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT Photodiagnosis and Photodynamic Therapy Volume 7, Issue 2 61 - 138 2010

S. Campbell, J. Tyrrell, R. Marshall and A. curnow Effect of MAL-photodynamic therapy on hypertrophic scarring Photodiagnosis and Photodynamic Therapy Volume 7, Issue 3 183 - 188 2010

J. Morris, T. Laing-Morton, P. Marno and A. Curnow An investigation into the awareness and understanding of the ultraviolet index forecasts in the South West of England. Photochemical and Photobiological Sciences   2010

S. Campbell and A. Curnow Clinical investigation of the novel iron chelating agent CP94, to enhance topical photodynamic therapy of nodular basal cell carcinome: further explanation of a dose-escalating pilot study conducted primarily to consider the safety of this pharmacological modification. British Journal of Dermatology Condence Section Volume 162, Issue 1 224-225 2010

A. Pye, Y. Dogra, J. Tyrrell, P. Winyard and A. Curnow Photodynamic Therapy with Aminolevulinic Acid and Iron Chelators: A Clinical Example of Redox Signaling Redox Signaling and Regulation in Biology and Medicine Book Chapter 15 381-404 2009

A. Curnow Basic Principles of PDT Clinical Photodynamics in Dermatology Volume 2 Number 1 Spring 2009 2 2009

S. Campbell Extending Applications for PDT Clinical Photodynamics in Dermatology Volume 2 Number 1 Spring 2009 4 - 5 2009

J. Tyrrell, S. Campbell, A. Shore and A. Curnow The utilisation of a non-invasive fluorescence imaging system to follow clinical dermatological MAL-PDT. IPA Congress 2009, Seattle, USA.   2009

E. Galley, R.M. Weightman, A. Curnow and T. Clifford From sweet confectionary to soothing skincare; the Marsh Mallow story. Cosmetic Science Technology  55-59 2009

S. Campbell and A. Curnow Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma: further explanation of a dose-escalating pilot study conducted primarily to consider the safety of this pharmacological modification British Journal of Dermatology Correspondence Section DOI 10.1111/j.1365-2133  2009

S. Campbell, C. Morton, R. Alyahya, S. Horton & A. Curnow Clinical investigation of the novel iron chelating agent, CP94 to enhance topical photodynamic therapy of basal cell carcinoma: results of the first clinical safety study British Journal of Dermatology 159 387-393 2008

S. Campbell and A. Curnow Extensive vulval intraepithelial neoplasia treated with a new regime of systemic photodynamic therapy using metatetrahydroxychlorin (Foscan) Journal of the European Academy of Dermatology and Venerology 22(4) 502-503 2008

A. Pye, S. Campbell and A. Curnow Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma. Journal of Cancer Research and Clinical Oncology 134(8) 841-849 2008

S.M. Campbell, C.A. Morton, R. Alyahya, S. Horton, A. Pye and A. Curnow Clinical investigation of the novel iron chelating agent, CP94 to enhance topical photodynamic therapy of nodular basal cell carcinoma. British Journal of Dermatology 159 387-393 2008

A. Curnow, A. Pye and S. Campbell. Experimental and clinical enhancement of PpIX-PDT achieved by the administration of an iron chelating agent. International Symposium on PDT &PD in Clinical Practice, Brixen, Italy   2008

A. Pye, A. Curnow Direct comparison of d-aminolevulinic-acid and methyl-aminolevulinate -derived-protoporphyrin IX accumulation potentiated by desferrioxamine or the novel hydroxypyridinone iron chelator CP94 in cultured human cells. Photochemistry & Photobiology Volume 83, issue 3 766 - 773 2007

A. Curnow and A. Pye  Biochemical manipulation via iron chelation to enhance porphyrin production from porhyrin precursors Journal of Environmental Pathology, Toxicology and Oncology  26(2) 89-103 2007

M. Whiteman, Y. Dogra, P. Winyard and J. Armstrong Methods in Molecular Biology. In redox Signal Transduction (Eds. Hancock J), Hamana Press, New Jersey, USA   2007

S. Campbell, A. Pye, S. Horton, J. Matthew, P. Helliwell and A. Curnow A clinical investigation to determine the effect of pressure injection on the penetration of topical methyl aminolaevulinate (MAL) into nodular basal cell carcinoma (nBCC) of the skin. Journal of Environmental Pathology Toxicology and Oncology Volume 26(4)  2007

A. Pye, L. Salter and A. Curnow The hydroxyp[yridinone iron chelator CP94 is superior to desferrioxamine at increasing PpIX fluorescence in cultured humand cells for phytodynamic therapy. EURO-PDT, Paris, France   2007

A. Curnow, A. Pye and S. Campbell. Enhancing PPIX production from porphyrin precursors using iron chelating agents. 11th IPA World Congress, Shanghai, China   2007

C. Morton, S. Campbell, G. Gupta, S. Keohane, J. Lear, I. Zaki,- S. Walton, N. Kerrouche, G. Thomas and P. Soto on behalf of the AKtion Investigators Intraindividual, right-left comparison of topical methyl aminolaevulinate-photodynamic therapy and cryotherapy in subjects with actinic keratoses: a multicentre, randomised controlled study British Journal of Dermatology 155 1029-1036 2006

R. Pottier, B. Krammer, H. Stepp and R. Baumgartner (ed).  Potential Future Indications.  Photodynamic therapy with ALA: A clinical handbook. Royal Society of Chemistry. Cambridge 249-259 2006

W. Bradfield, A. Pye, T. Clifford, L. Salter, D. Gould, S. Campbell & A. Curnow Hg(II) exposure exacerbates UV-induced DNA damage in MRC-5 fibroblasts: A comet assay study Journal of Environmental Science & Health Part A 41 143-148 2006

N. Morley, A. Rapp, H. Dittmar, L. Salter, D. Gould, K. Greulich & A. Curnow UVA induced apoptosis studied by new apo/necro-comet assay which distinguishes viable, apoptotic, and necrotic cells Mutagenesis 21 (2) 105-114 2006

A. Curnow, A.J. McRobert & S.G. Brown Comparing and combining light dose fractionation and iron chelation to enhance experimental photodynamic therapy with aminolaevulinic acid Lasers in Surgery & Medicine 38 325-331 2006

S. Bennett, J. Bastin, L. Salter, A. Watt & J. Morris Cornwall's funding does not fit its rurality British Journal of Health Care Management 11, No.5 142-147 2005

J.M. Morris, D.J. Gould, S. Bennett, J. Bastin, L. Salter & A. Watt Sun protection initiatives in Cornwall.  Clinical & Experimental Dermatology 30 340-343 2005

N. Morley, T. Clifford, L. Salter, S. Campbell, D. Gould & A. Curnow The green tea polyphenol epigallogatechin gallate and green tea can promote human cellular DNA FROM ultraviolet and visible radiation-induced damage Photodermatology, Photoimmunology, Photomedicine 21 15-22 2005

L. Salter, N. Morley, T. Clifford, S. Campbell, D. Gould & A. Curnow The use of comet assay data with a simple reaction mechanism to evaluate the relative effectiveness of free radical scavenging by Quercetin, Epigallocatechin gallate and N-acetylcysteine in UV-irradiated MRC5 lung fibroblasts Journal of Photochemistry and Photobiology B: Biology 75 57 - 61 2004

S.M. Campbell, D.J. Gould, L. Salter, T. Clifford & A. Curnow Photodynamic therapy using meta-tetrahydroxyphenylchlorin (Foscan) for the treatment of vulval intraepithelial neoplasia. British Journal of Dermatology 151 1076-1080 2004

N. Morley, A. Curnow, L. Salter, S. Campbell & D. Gould N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts Journal of Photochemistry and Photobiology B: Biology 72 55 - 60 2003

B. Parsons, L. Salter, T. Coe, R. Mathias, R.J. Richards & T.P. Jones Airborne particulate matter (PM10) in the China Clay area, Cornwall, UK Mineralogical Magazine 672 163 - 171 2003

B. Parsons & L. Salter Air quality effects of traffic in a canyon-like street (Falmouth, UK) Environmental Monitoring & Assessment 82 63 - 73 2003

H. Tsutsui, A.J. MacRobert A. Curnow, A. Rogowska, G. Buonaccorsi, H. Kato & S.G. Bown  Optimisation of illumination for photodynamic therapy with mTHPC on normal colon and a transplantable tumour in rats  Lasers in Medical Science  17  101-109 2002

N. Komerik, A. Curnow, A.J. MacRobert, C. Hopper, P.M. Speight & M. Wilson Fluorescence biodistribution and photosensitising activity of toluidine blue O on rat buccal mucosa Lasers in Medical Science 17 86-92 2002

A. Curnow & S. Bown The role of reperfusion injury in photodynamic therapy with aminolaevulinic acid - a study on normal rat colon British Journal of Cancer 86 989 - 992 2002

A. Curnow, L. Salter, N. Morley, S. Campbell & D. Gould Paracetamol can exacerbate irradiation-induced DNA damage British Journal of Clinical Pharmacology 53 338 - 340 2001

A. Curnow, B. Parsons, L. Salter, N. Morley & D. Gould Investigation of the genotoxic effects of airborne particulate matter using single cell gel electrophoresis Indoor and Built Environment 10 258 - 260 2001

A. Curnow, L. Salter, N. Morley & D. Gould A preliminary investigation of the effect of arsenate on irradiation-induced DNA damage Journal of Toxicology and Environmental Health Part A, 63 101 - 112 2001

A. Curnow, J. Haller & S. Bown Oxygen monitoring during 5-aminolaevulinic acid induced photodynamic therapy in normal rat colon: comparison of continuous and fractionated light regimes Journal of Photochemistry and Photobiology B: Biology 58 149 - 155 2000

A. Curnow, B.W. McIlroy, M.J. Postle-Hacon, A.J. MacRobert & S.G. Bown Light dose fractionation to enhance photodynamic therapy using 5-aminolaevulinic acid in the normal rat colon Photochemistry and Photobiology 69 71-76 1999

A. Curnow, M.J. Postle-Hacon, A.J. MacRobert & S.G. Brown Enhancement of 5-aminolaevulinic acid induced photodynamic therapy using light dose fractionation and iron chelating agents SPIE Conference Proceedings; Optical methods for tumour treatment and detections; Mechanisms and Techniques in Photodynamic Therapy VII 3247 118 - 127 1998

A. Curnow, B.W. McIlroy, M.J. Postle-Hacon, J.B. Porter, A.J. MacRobert & S.G. Bown Enhancement of 5-aminolaevulinic acid induced photodynamic therapy using iron chelating agents British Journal of Cancer 78 1278 - 1282 1998

B.W. McIlroy, A. Curnow, G. Buonaccorsi, M.A. Scott, S.G. Bown & A.J. MacRobert Spatial measurements of oxygen levels during photodynamic therapy using time-resolved optical spectroscopy Journal of Photochemistry and Photobiology: B: Biology 43 47 - 55 1998

G. Patel, D. Gould & J. Hawk A complex photodermatosis solar urticaria progressing to polymorphic eruption Clinical Experimental Dermatology 23 77 - 78 March 1998

B. Cordi, M. Depledge, D. Price, L. Salter & M. Donkin Evaluation of chlorophyll fluorescence, in vivo spectrophotometric pigment absorption and ion leakage as biomarkers of UV-B exposure in marine macroalgae Marine Biology 130 41 - 49 1997

C.J. Twelves, N.A. Dobbs, A. Curnow, R.E. Coleman, A.L. Stewart, C.J. Tyrell, P. Canney & R.D. Rubens A phase II, multicentre, UK study of vinorelbine in advanced breast cancer British Journal of Cancer 70 990 - 993 1994

B. Parsons & L.F. Salter The effect of distant sources of ozone and PM10s on boundary layer air quality in Cornwall - a rural area in the UK. In Global Atmospheric Change and its Impact on Regional Air Quality ed I Barnes NATO Science Series IV Earth and Envirnmental Sciences Vol 16 Kluwer Academic, Dordrecht (Proceedings of the NATO Advanced Research Workshop on Global Atmospheric Change and its Impact on Regional Air Quality Irkutsk, Russian Federation, August 21 - 27, 2001) 273 - 278 1994

News

11th September 2012: Clinical Photobiology Research in the 'Media Spotlight'

5th July 2012: Researching a cellular link between radon and skin cancer

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Recent Publications

Radon and skin cancer in Southwest England: an ecologic study written by B. Wheeler, J. Allen, M. Depledge and A. Curnow

Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methylaminolevulinate photodynamic therapy. written by E. Blake, J. Allen, C. Thorn, A. Shore, A. Curnow.

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Recent Presentations

A novel experimental system to expose human cultured cells to radon and its daughter products. written by A. Robertson, J. Allen, R. Laney and A. Curnow.

An in vitro comparison of the interactive effects of benzo[?]pyrene and ultraviolet radiation on mammalian and fish cells written by J. Allen, Z. Lyle, A. Jha and A. Curnow

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