Project Summary and Objectives:
Major depressive disorder is common in patients with chronic medical
conditions. This comorbid major depressive disorder magnifies patients'
suffering, reduces their quality of life and adds burden on their carer
and on the health service. It is also under recognised and inadequately
treated. This study is part of a programme of research that aims to
improve the management of comorbid depression in outpatients with advanced
or recurrent cancer. Phase one, the development of an efficient method of
screening for depression, is already underway. Phase two, is the
development and initial evaluation of a new multifaceted oncology nurse
delivered intervention. Phase three will be a formal multicentre
randomised comparison of the effectiveness of the new intervention and
usual care for patients identified as having major depression by routine
Publications to date:
Strong V, Waters R, Hibberd C, Murray G, Wall L, Walker J, McHugh G, Walker A, Sharpe M. "Management of depression for people with cancer (SMaRT oncology 1): a randomised trial." Lancet 2008; 372: 40-48
Sharpe M, Strong V, Allen K, Rush R, Maguire P, House A, Ramirez A, Cull A. "Management of major depression in outpatients attending a cancer centre: a preliminary evaluation of a multicomponent cancer nurse-delivered intervention." British Journal of Cancer (2004) 90, 310-313.
Sharpe M, Strong V, Allen K, Rush R, Postma K, Tulloh A, Maguire P, House A, Ramirez A, Cull A. "Major depression in outpatients attending a regional cancer centre: screening and unmet treatment needs." British Journal of Cancer (2004) 90, 314-320.
information may be obtained from:
School of Molecular & Clinical
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