|
Project Summary and
Objectives:
Incorporation of quality of life (QOL)
assessments in clinical trials is increasing and it is becoming widely
accepted by health and medical professionals that QOL measurements are
equally as important as survival measures.
The study described here has a
primary aim to compare the use of a cross-sectional survey with a
longitudinal survey to evaluate QOL and sexual activity.
Longitudinal studies provide
comprehensive data indicating changes over time for individual patients,
but are potentially expensive and are often subject to incomplete
follow-up data as a result of patient non-compliance. Cross-sectional
studies, however, are much simpler and cheaper, but variation in an
individual patient’s health status over time cannot be assessed.
The researchers hypothesis is that a
cross-sectional survey can adequately detect differences between
treatments and also time trends in QOL within groups of patients without
having to rely on labour-intensive longitudinal studies.
The secondary aim of the study is to
determine the effects of interferon-alpha on QOL in advanced ovarian
cancer patients, placing particular emphasis on the effect on sexual
activity.
Publications
Stead, M. L., Crocombe, W. D., Fallowfield, L. J.,
Selby, P., Perren, T. J., Garry, R., and Brown, J. M. (1999) Sexual
activity questionnaires in clinical trials: acceptability to patients with
gynaecological disorders., British Journal of Obstetrics
and Gynaecology (January 1999, Vol 106, pp. 50-54)
Further information can be
obtained from:
Mrs Maxine Stead
Head of Trial Co-ordination Section
c/o Northern and Yorkshire
Clinical Trials and Research Unit
Yorkshire Cancer Organisation
University of Leeds
Arthington House
Hospital Lane
Leeds LS16 6QB
UK
|