Project Summary and
uncertainty as to the optimal management of mildly abnormal smears.
One approach is a repeat smear in 6 months to enable regression to normal.
The alternative is to colposcope, with the advantages of prompt diagnosis
and reducing default.
There is a lack of professional concensus as to which of these two is
A major consideration is psychological morbidity and quality of life.
The objective of the study is to determine whether the psychological
outcome for women with mildly abnormal smears is better if they are able
to decide the first stage of their management.
500 women with a mildly dyskaryotic smear or recurrent borderline smear
will be randomised either to cytological surveillance with colposcopy if
smears remain abnormal or to the patient choosing between
cytological surveillance or colposcopy.
Primary outcomes will include psychological morbidity, quality of life and
rates of default in each arm.
Secondary outcomes will include the proportion of women in each arm
requiring colposcopy and treatment.
Further information can be
Professor Henry Kitchener
Professor of Gynaecological Oncology
Department of Obstetrics & Gynaecology and Reproductive Health Care
University of Manchester
St. Mary's Hospital
Manchester M13 0JH