Aims and Objectives
The aim of the project is to decorate a novel nanoparticle vaccine with immunogenic chemistry that will produce an intense immune response. Careful choice of immunogenic species may also control the MHC1/MHC2 presentation of antigens.
- Design and build new nanovaccine candidates
- Develop in vitro assay technology
- Control MHC1 and MCH2 response
- Characterise the antibodies and concentration produced by the antibodies.
Gregory, A.E., Williamson, E.D., Prior, J.L., Butcher, W.A., Thompson, I.J., Shaw, A.M., Titball, R.W. (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine, 30(48), 6777-6782
Gregory AE, Shaw AM, Titball RW, Williamson ED, Prior JL, Butcher WA, Thompson IJ
Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity